Exact original location is unknown. The Buffalo-Pittsburgh Highway generally followed parts of todays U.S. Routes 119 and 219.
LIkely McKean, where the town of Kane is located.
Large, post-mounted keystone
Sadly, all of these large keystones which once marked the summits of major-highway ridge crossings have disappeared and such locations are now marked by a simpler less-iconic marker.
This gigantic keystone marker-shaped, two-paneled sign announced to highway travelers that they had reached Kane Summit
Kane Summit Sign on eBay. Different angle. Older edition. JGl
Specific location unknown